Endocrine Abstracts

A 64-year-old lady presented feeling unwell with nausea, vomiting, headaches and dizziness. She was taking sulpiride for schizophrenia and had an 8-year history of hyponatraemia. The hyponatraemia, was associated with mild hyperprolactinaemia, prompting investigation for hypopituitarism twice previously by endocrinologists in a different hospital. Secondary adrenal insufficiency had been excluded on the basis of: cortisol 576 nmol/l at 30 min after 250 mcg synacthen and cortis...

Background: Thyrotropin-secreting pituitary adenomas (TSH-omas) account for 1% of pituitary tumours. In addition to TSH, these tumours frequently secrete glycoprotein α-subunit (αSU) and up to 50% are immunoreactive for growth hormone (GH), although GH suppression following oral glucose tolerance testing (OGTT) has not been routinely performed in all patients to identify subclinical GH hypersecretion or abnormal GH suppression.Objectives: To ex...

Background: Prolactin levels are affected by stress, and in patients with moderate hyperprolactinaemia, a repeat test and/or a resting prolactin has been recommended, but there are very few data addressing the utility of these additional measurements.Aim: To study the value of: A) Repeat measurement and B) Resting measurement of serum prolactin in mild to moderate prolactin excess (510–7500 IU/L).Methods and subjects: Case not...